Losing even 10% of your total body weight can significantly lower your risk. What you eat and the pattern of your eating are going to determine how intermittent fasting will work for you. Practice portion control and eat till your 80% full. Feed yourself with nourishing food whenever you feel hungry, even if it requires breaking your fast.
They should be avoided by people who are overweight or obese. Very low-fat diets may be difficult for all but the most motivated and disciplined people.